*The following is a summary of the research project that I worked on during the 1st rotation of my Ph.D. in Pharmacology and Molecular Sciences at Johns…… Read more “Blocking Glutamine Metabolism with DON Promotes Differentiation of AML Cells”
The Expanding Scope of DNA Sequencing
*Note: The following is an adaptation of various excerpts from the paper of the same name, “Expanding to scope of DNA sequencing” (Shendure & Aiden, 2012) [1].…… Read more “The Expanding Scope of DNA Sequencing”
The Immuno-oncology Revolution: CAR-T Therapies
[View PDF Version] [View Author’s LinkedIn] Institutional and Political Backing On May 2015, Joseph Robinette “Beau” Biden III, the elder son of…… Read more “The Immuno-oncology Revolution: CAR-T Therapies”
The Expansion of RNA-targeting Therapeutics
[View PDF Version] [View Author’s LinkedIn] The Substrate of Protein Expression RNA has important and diverse roles in biology which include, but…… Read more “The Expansion of RNA-targeting Therapeutics”
Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy
[View PDF Version] [View Author’s LinkedIn] Thesis Glucose and glutamine supply fuel protein O-GlcNAcylation in T cells via the HBP, which in…… Read more “Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy”
Glutathione Primes T Cell Metabolism for Inflammation
[View PDF Version] [View Author’s LinkedIn] Metabolic T-cell Activation T-cells are activated when their T-cell receptors (TCRs) are engaged by cognate peptide-MHC…… Read more “Glutathione Primes T Cell Metabolism for Inflammation”
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
[View PDF Version] [View Author’s LinkedIn] Clinical Background The chemotherapy backbone – a combination of cytarabine and an anthracycline – has remained…… Read more “Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia”
In Brief – Fluorescence Resonance Energy Transfer (FRET)
[View PDF Version] [View Author’s LinkedIn] Paper: “Protein-guided RNA dynamics during early ribosomal assembly.” Uses in the Paper: The FRET assay was…… Read more “In Brief – Fluorescence Resonance Energy Transfer (FRET)”
Kevin O’Leary’s Three-pronged Persuasive Strategy
[View PDF Version] [View Author’s LinkedIn] In 2005, the Canadian businessman, venture capitalist, and co-host on the hit ABC reality television show…… Read more “Kevin O’Leary’s Three-pronged Persuasive Strategy”
Jonas Salk’s Professional Downfall
*Note: The following is an adaptation of various excerpts from the book Give and Take by Adam Grant. [View PDF Version] [View…… Read more “Jonas Salk’s Professional Downfall”
Biomed Affinity 